Reconstruction 1965-77 a false dawn for African-American Civil Rights Essay

To what Degree was Reconstruction 1965-77 a false dawn for African-American civil Rights? After the end of the civil war, there were many issues which needed to be addressed. The civil rights of the African American’s were in need of change, and during this period there were hopes that new legislation would be implemented to aid African Americans and other minority groups. This legislation would be called the Civil Rights Act of 1866, the 14th Amendment of 1868 (which promised equality), and finally the 15th Amendment (which gave the right to vote). However, despite the positive legislation, reconstruction aggravated a lot of people and brought the southern states into conflict with the Government. The Freedmen’s Bureau was established in 1865, which aimed to provide food, clothing, and fuel to formal slaves and white refugees. The Freedmen’s Bureau bill was also passed by Abraham Lincoln; however Johnson vetoed it, however a supplementary act extended its existence until 1870. This was very good for black rights, as it gave blacks more protection and a safety net if they were too poor to buy food and support their families. However, it was only meant as a temporary act, and therefore there was always the looming feeling that it would soon come to an end, and also the promises of it were not fulfilled to the extent at which it was said to be. The Amendments which were introduced also gave black people a real hope in gaining independence and freedom. The 13th amendment was introduced in 1865, and this guaranteed the permanent abolishment of slavery. The emancipation proclamation which was introduced by Abraham Lincoln was seen as more of a temporary fix whilst the war was going on, however the 13th amendment solidified it and made it a more permanent and clear reality. â€Å"Section 1. Neither slavery nor involuntary servitude, except as a punishment for crime where of the party shall have been duly convicted, shall exist within the United States, or any place subject to their jurisdiction.† However, although by law it states that there shall be no slavery, slavery continued on a more hidden basis. Sharecropping still existed, and freedmen who had come out of slavery with no qualifications or experience became unemployed, so the living conditions for most freedmen did not improve. Slave-owners were also reluctant to let their slaves leave, and often kept them illegally. The 14th Amendment however was introduced in 1870, and this aimed to further secure the rights of the freedmen. This turned out to be one of the most important Amendments ever made to the American constitution. It threatened to reduce the representation of the states which continued to discriminate. However, a loophole in this law was that the states which continued to discriminate would just accept the unequal representation, but carry on with their discrimination, yet just not so obvious. Therefore by some, this could be seen as a false dawn, as it did address the issue of freedmen not having rights, but it also created a loophole for the southern states to take advantage of. The 15th Amendment was introduced two years later, which aimed to cover the loophole which was created by the 14th amendment. This stated: â€Å"Section 1. The right of citizens of the United States to vote shall not be denied or abridged by the United States or by any State on account of race, color, or previous condition of servitude† This was a huge step forward for black civil rights, as this means that the south was not able to carry on with their discrimination against many voters, and this nullified the loophole in the law which was created by the 14th Amendment. However, more loopholes were created with this, with unattainable requirements being implemented just to be able to vote. For example, voters in some states had to be taxpayers which was not possible for freedmen, as most were not earning enough to be able to pay tax, and also literacy tests were introduced which were severely biased against black people, with questions which were completely unanswerable. Another reason why this did not entirely work was because of the uprising of the KKK. They were a terrorist group which aimed to scare black people into not voting, and to basically cause terror because they were black. They at first were not an ultra-violent group, however as time progressed they quickly became increasingly violent, as lynchings were common, and they would often target the black people who were doing well for themselves, I.E lawyers who were doing a lot for civil rights, or those who went to vote. Because of this huge suppression and hatred, a lot of black people were scared to vote and in reality voting was not a freedom for black people. Some historians would say that reconstruction it itself did not really care for the black rights, and that it was a political move to try and remain Republican power in the south. Abraham Lincoln himself did not have a clear policy for freed slaves after the Civil War, so reconstruction was not seen as a solid plan from the start, it was looking like a false dawn. â€Å"False Dawn† – â€Å"something which seems to show that a successful period is beginning or that a situation is improving when it is not.† â€Å"Reconstruction† – â€Å"The act of constructing again, of rebuilding† Bibliography – * Wikipedia * Class Notes * Civil Rights In America – Ron Field * About.com

Interrail Pass Integrated Marketing Communication Plan Essay

The main difference between the EuRail and the InterRail is simply based on the passenger’s country of residency. The EuRail is available to residents of a non-European country and the InterRail is available for European residents only. You can be eligible for the InterRail if you have been a resident in a European country for at least 6 months. EuRail and InterRail Passes are widely known as the best rail passes in Europe, having the ability of flexibility by its large range of options. The main audience in the market for the InterRail are a highly 74% youth, having the highest sales in UK, Germany, Switzerland, Spain and Sweden. The InterRail Global Pass, valid for travel in 30 European countries, is still and remains for the 5 year the most popular option among the audience of youth travellers under 26 years old. But within the Global pass, there is dominance for the flexible travel. Due that is in high demand, it is clearly visible that the 10 travel days within 22 days is the most popular product for travellers not wishing to travel everyday of their vacations. One Country pass are Italy and Germany that combined form 62% of the market share. EuRail Group reports an audience of over 248,000 Europeans explored Europe by train. The biggest strength that InterRail has it that is a unique selling product in within the travel market. There is no other kind of pass similar to the InterRail, giving a huge advantage on the market place. Their only competition in a certain way will be the airlines, giving in some cases cheaper tickets or having a faster route. Other mayor strength is they have gathered all of the companies their users are more likely to need in their travels, and create a partnership between them, giving the user benefits and promotions in their services and products. A weakness for the product is that the trains can be highly confusing for the people that have never before use them, making that niche of the audience prefer that actual airplanes. Also there is an speculation in the internet about, the difficulties there are when booking a train with the pass. The Opportunities in within this product will always be to get as much destinations as possible. In within the travel market, the best agency will take you every place you want to go. Creating for InterRail, only a matter of agreements and routes to increase the diversification in the audience and options for the users. A Threat that I found on the market was the airplane because they can travel over seas, giving the advantage in some determined routes takes less time to arrive to the destination rather than the trains, making them look slower and therefore not functional. The Main objectives of the InterRail are to create, manage and target the increasingly comprehensive InterRail passes. Working to generate widespread awareness of the benefits of rail travel for the traveller. One of the Marketing Communication Strategies the product will be using is to emphasis on the brand differentiation with the airplanes. Letting know our audience and market, the benefits of using a train and with that, the InterRail. In here, the plan is to include us and other companies in a generic campaign, fighting for the environment. This would help the market to know, that using a train is more environmental friendly. Current Market Situation When the first InterRail Pass was launched on March 1, 1972 it was managed in conjunction by a large number of train and shipping companies. These companies were starting the business of an overall pass that could unite the traveling experience and save money traveling by train at the same time. In 2001, the EuRail Group was established as an organization dedicated to the marketing and management of the EuRail pass. The EuRail Group is wholly owned by the participating railways and shipping companies with key decisions being taken by the board, consisting of eight appointed member railways. In addition, the Group has many benefit partners, including hotels, transport companies, and museums, which offer their services either at a reduced rate or free of charge for rail, pass holders. In 2007 the EuRail group took over the InterRail pass, to give a more commercial focus. The Market of the InterRail has existed since 1972; there have been several changes. The first InterRail ticket was targeted towards backpacking students under the age of 21 travelling around Europe on a limited budget and cost around 118 euros. The age limit for availing of an InterRail holiday increased from 21 to 23 in 1976 and rose to 26 years in 1979. InterRail targets its rail passes to European residents of all ages and budgets. The highest sales originate in the UK, Germany, Switzerland, Spain and Sweden. Around 74% of InterRail customers are youth, under the age of 26. The proportion of young travellers is higher for the InterRail Global Pass; 79,7% of customers are youth. For the One Country Pass, this proportion is 62,1%.. EuRail Group reports a positive full year of sales for the fifth year running. They had over 248,000 Europeans explored Europe by train. Compared to 2010, the month-to-month sales followed a similar pattern that on 2010. But there were some changes in the months of April and May. These two months were more productive than last year, having a positive sale of 11% for April and 14% growth in May. Also there has been and increase on online sales if InterRail passes, being a 25% amount of the total sales. The InterRail Global Pass, valid for travel in 30 European countries, is still and remains for the 5 year the most popular option among the audience of youth travellers under 26 years old. But within the Global pass, there is dominance for the flexible travel. Due that is in high demand, it is clearly visible that the 10 travel days within 22 days is the most popular product for travellers not wishing to travel everyday of their vacations. In second hand, we have the InterRail one country pass, also having a significant increase of 5. % in sales. The most popular destinations for traveling with the One Country pass are Italy and Germany that combined form 62% of the market share. The Travellers purchasing this pass are interested in visiting one particular country and explore it in depth. The EuroRail Group estimates to see continued growth for the InterRail passes, even with the challenging current European economic state. Mr. de Groot, Managing Director of the EuRail Group said: â€Å"Whilst growth remained modest for the InterRail Global Pass, we still welcomed an additional 5. 00 passengers last year. This reconfirms that InterRail Passes are still an excellent way to explore Europe. We are therefore confident that InterRail sales will continue to grow in the years to come as more and more Europeans discover the real value for money this pass represents† SWOT and Market Analysis In the SWOT analysis we get to describe the strategic planning method used to evaluate the Strengths, Weaknesses, Opportunities and Threats that are involved in a business venture. The analysis divides into two many factors, Internal and External. The Internal factors are the strengths and the weakness of the organization. The External factors are the Opportunities and Threats presented by the external environment to the organization. One of the biggest Strengths of the InterRail is that the EuRail Group has total control over the market, as I see it, it`s a Monopoly. I research for a competition pass, another company that was doing something similar, but I found none. This is because the EuRail Group belongs to the most powerful train companies in Europe, leaving no market space for any other company to equal their promotions. Their only competition in a certain way will be the airlines, giving in some cases cheaper tickets or having a faster route. But they make sure their costumers get what there are looking for, and that will be discount and saving money. EuRail Group has many benefit partners, including hotels, transport companies, and museums. This is another strength for the InterRail; they have gathered all of the companies their users are more likely to need in their travels, creating a microenvironment between them. Some benefits InterRail pass holders have are discounted and free ferry travels on various European crossings. An example can be, that the pass holder can travel free in a ferry between Italy and Greece and even can stop off in the Island of Corfu with no charges. Another strength the InterRail pass is the reputation it has in its marketplace. Since I’ve been to Europe in 2009 to travel with pass, every person I know from then, that has a relatively experience in travel in Europe or has been planning to do so in the near future, has the perception that the InterRail pass is the best way to travel, not only to get to know all of Europe in a short amount of time, but also a way to do explore and save money for other things. Another strength that InterRail has compared to airlines is that most of the stations are in the heart of the city, making it easy to move when arriving to your destination. As everything in life, there are strengths and weaknesses. The hard part about describing a weakness in this product is that they are the only product for this market. But there are a few we can talk about. One of the first weaknesses I found when starting to research was that at first, the InterRail was design for young people to get to travel around Europe for a low amount of money. But things have change, since the beginning of the InterRail; the pass has been changing its rules to travel. At first there was only a global pass, an unlimited month, were you can get in any train you want in the determined month you selected. But know, there is a different story. InterRail has now broken into several passes. Creating a new and different way to travel, having more options, because Europe had been divided into areas. However, some young people believe that the new-zoned tickets have destroyed the original InterRail concept, which allowed unlimited travel over a set period. Leaving the impression that the InterRail is to make profits, and not to help the traveler. Another weakness that I discover was the airplanes. As I began to research, general population of the InterRail had some problems with the booking of trains, they said that they didn’t know that some trains needed to be booked in advance or they didn’t know the difference within the ones you have to book or the ones who don’t. Creating an opinion that is safer to go in plane because you have secure you place in the plane when buying your ticket. Another weakness the InterRail has the trains cant leave the tracks, therefore having to create first the route with track to make the journey possible. The External factor of the InterRail are to be consider, these factors determine the position and structure EuRail Group has to market to be well placed in within the market. The opportunities InterRail has in the market are beginning to getting achieved. As you have read, the InterRail only moves within Europe. But what about Morocco, Libya, Iran Saudi Arabia or even better Mexico. The Opportunities in within this product will always be to get as much destinations as possible. In within the travel market, the best agency will take you every place you want to go. Creating for InterRail, only a matter of agreements and routes to increase the diversification in the audience and options for the users. Another Opportunity the InterRail can have, to create another kind of pass called â€Å"The Group†. This pass will have an itinerary and a trip already planed with nticipation, but the user gets to travel all the time with a group of 10 people, creating the experience of getting to know a new country or city with new people. Therefore the InterRail will become something more than just a pass, but the creator of a full experience trip. The Threats to this organization, the EuRail Group, has been and always be the airplane market. Because of that, the airlines become a direct competitor for the InterRail. This other different market basically does the same but has its difference. In the general outcome of airplanes, at first were considered annoying because of the separation between the city and the airport, the check in for the baggage and the long waiting hours to clime the plane. But all of this has given the InterRail some fight. Another advantage of the plane is that they can travel over seas, giving the advantage in some determined routes takes less time to arrive to the destination rather than the trains, making them look slower and therefore not functional. When booking a flight within 3 or more weeks in advance is a threat for the InterRail, because the airlines can assure very low prices. Another threat that came to me researching the airplanes market was the very low prices they can have in some flights. There is a website called lastminute. com, this website has flights opened at the last minute, 3 days before departure in some cases, and are sold at low prices. Another possible threat is the organization of the most powerful bus companies in Europe. Imagine creating the same pass the trains have, but creating a network of buses that could take you every were you want in the continent. Creating a similar but profitable competition for the InterRail a much cheaper way to travel in within Europe. This could be a niche even smaller than the one InterRail actually posses but can be a start, for the pass to be knowledgeable in the market place. As a general market analysis, the InterRail is in great positioning on the travel market. Giving the ability to travel all around Europe for a low cost, providing destination to every corner. The strength of the product makes it an incomparable experience, due to the factor that is an network of companies that have to share the expenses on the railing, and by that case, created an group for that same reason. As for the railing, its part of it weakness because of the fact that a railway route has to be made in order to create the destination, but what about those destination, not much frequent, but get to have a share in the audience options. Will it be profitable to have that destination; will it be profitable to have the railroad made? There is a lot to be discovered in this market but the most intriguing part of all its future are the opportunities they have to become bigger, to expand to different countries to different continents. Also the rapid innovation on train machinery makes the trains arrive faster at their destination and become more profitable an even more environmental friendly. For last, the most direct competitors for the InterRail are the airlines. They can have lower prices for longer destination, creating a disadvantage for the InterRail. Also can be considering the conjunction of the bus owners, having the same effect as the EuRail Group.

Operating Room Observation Paper Essay

Patient: J.D. Age: 39 year-old. Gender: Female. Marital status: Married. Chief complaint: Left tendoachilles pain for 5 years. Patient rates pain to 10/10. Patient said she had a Platelet-Rich Plasma (PRP) injection 2 years ago as a treatment intervention for this condition and had some relief but over time, the pain came back and got worse. Name of surgical procedure: Endoscopic Gastrocnemius Recession. Surgery: Left leg Gastrocnemius Recession. This procedure is to release a tight calf muscle that is pulling the heel upward. To improve ROM(Range Of Motion), the tendon connecting to the tight calf muscle will be cut, this will release the heel from the upward pull allowing the patient to stand with foot flat on ground. Gastrocnemius Recession is commonly performed to correct an equinus contracture of the ankle that may accompany foot and ankle pathology in adults. (An equinus deformity is basically one in which the achilles tendon is shorter than needed to allow adequate dorsiflexion during the gait cycle.  If the foot is perpendicular to the leg and put through a range of motion where the foot cannot dorsiflex (move upward) more than 10 degrees this is thought of as an equinus deformity). The equinus deformity leads to excessive pressure and pain that manifests as plantar fasciitis, metatarsalgia, posterior tibial tendon insufficiency, osteoarthritis, and foot ulcers. The procedure is also performed on individuals who have limited ankle dorsiflexion. Preoperative phase. In the preoperative phase, many informations are obtained, a full history from the client, including allergies, medication usage, and pre-existing medical conditions. Any previous experiences with sedation or anesthesia should to be reported, especially any adverse reactions. Note the last dose of each of the client’s prescribed medications, especially if it could alter the client’s response (diuretic, antihypertensive, narcotic). Provide education about the procedure and the medications to be used. Perform a full assessment on the client, including baseline vital signs, cardiac rhythm, and level of consciousness. Determine the last time the client ate or drank (generally NPO for 6 hrs or more before the procedure). The client may have clear liquids up to 2 hrs before the surgery or procedure. Instruct the client to adhere to the instructions to remain NPO, or the surgery or procedure may be cancelled. Establish IV access and administer fluids as prescribed. Verify that the client signed the informed consent. Attach monitoring equipment to the client. Remove dentures (in case intubation would become necessary). Anxiety level is also assessed regarding the procedure, and coping mechanisms. Diagnostic test. Usually many diagnostic test are performed, including Urinalysis, CBC, ECG, chest X-ray for heart and lung status and also for this case since my assignment patient was a female, a pregnancy test was performed, which came  out negative. Informed consent. Usually once surgery has been discussed as treatment with the client and significant other, family member, informed consent is obtained after discussing the risks and benefits of the procedure. To obtain informed consent, the provider must give the client a complete description of the treatment/procedure. A description of the professionals who will be performing and participating in the treatment Information on the risks of anesthesia. A description of the potential harm, pain, and/or discomfort that may occur. Options for other treatments and the right to refuse treatment. The patient must give informed consent voluntarily. And the nurse is to witness the patient sign the consent papers. The procedure/Intraoperative. The nurse remains with the client at all times. Allow other staff to assist the provider with the procedure, if indicated. Continually assess and monitor level of consciousness, cardiac rhythm, respiratory status, and vital signs. During the procedure, the following equipment must be present within immediate reach for routine monitoring and in case deep sedation with respiratory depression occurs. Fully equipped emergency cart that includes emergency medications, airway and ventilator equipment, defibrillator, and IV supplies. A 100% oxygen source and administration supplies, airways, manual resuscitation bag, and suction equipment. ECG monitor/display, noninvasive blood pressure monitor, pulse oximeter, thermometer, and stethoscope. The patient is placed in a supine position with leg elevated, and the surgical assistant prepares the surgical site by cleaning it appropriately. This procedure is performed with general anesthesia. When ready, an incision  is made on the back inside part of the lower leg and the gastrocnemius tendon is exposed. Once the tendon is exposed, the procedure is performed by releasing it as you can see it on the monitors. This effectively lengthens the calf muscle. Patients will now have the same ankle motion with their knee straight that they previously had with their knee bent. After the calf muscle is lengthened, the wound is closed up. This was a fairly quick procedure, about 35-40 minutes. Postoperatively, the patient is escorted to the post anesthesia care unit by the anesthesiologist and the circulating nurse who gives a verbal report to the post anesthesia care unit nurse. Initial postoperative care involves making assessments, administering medications, managing the client’s pain, preventing complications, and determining when a client is ready to be discharged from the PACU. During the immediate postoperative stage, maintaining airway patency and ventilation and  monitoring circulatory status are the priorities for care. Since my assigned patient was administered general anesthesia, frequent respiratory status was required. The nurse who is monitoring continues to record vital signs and level of consciousness until the client is fully awake and all assessment criteria return to presedation levels. Only then can the nurse remove the monitor and all emergency equipment from the bedside. Typical discharge criterias are level of consciousness as on admission, vital signs stable for 30 to 90 min, ability to cough and deep breathe, ability to tolerate oral fluids, ability to void, absence of nausea, vomiting, shortness of breath, or dizziness. And the patient is then transferred to a post surgical unit where the patient is still being monitored for any sign of complications. The surgical leg is stabilized and put in a boot that will be in place for about 2-6 weeks. Patient teaching is done including telling the patient to keep leg elevated and keep weight off the foot. And pain level is assessed, patient is medicated as needed. Healing time for this procedure can be short or can take longer based on a some factors like nutrition, circulation, medical condition and also lifestyle, per example if you are a smoker, it will take  longer. The patient was discharged to home the same day since it was an outpatient surgical procedure. http://www.footeducation.com/gastrocnemius-slide-strayer-procedure http://www.aaos.org/news/bulletin/oct07/clinical4.asp http://www.instratek.com/userfiles/EGRTechniqueGuide.pdf http://www.ankleandfootcare.com/research/japma_vol95_no4.pdf http://whymyfoothurts.com/conditions/equinus.html

Ethics Panel for Post-Graduates Essay Example | Topics and Well Written Essays - 1000 words

Ethics Panel for Post-Graduates - Essay Example ict between the patients experience and nurses assessment of the pain will be used to help formulate a better framework for pain assessment in patients. (For example, outline of research methodology, what information/data collection strategies will you use, where will you recruit participants and what approach you intend to take to the analysis of information / data generated) Due to the subjectivity of pain experience a qualitative method will be used for this study, which seeks to provide a perception of how or why things are as they are. It means that the gathered primary research information will have come from different sources of personal and professional experiences. Data will be collected through a one on one semi-structured interview of nurses and patients. This is only fitting considering that Hancock (1998) relates that data collection in a qualitative research involves direct encounters with individuals through one to one interviews. In-depth interview allows intensive exploration of a topic with someone who has had related experiences. Open-ended questions will be used during the interview. This is in contrast with close-ended questions which may limit further exploration of the participants’ experiences. Typically the recommended sample for grounded theory is about 20 to 30 participants (Polit & Beck, 2006). Determining the sample size depends on the quality and richness of the data. This research will aim to involve 20 nurses and 20 patients. Once ethical approval is gained, the researcher will send a formal letter to the hospital administration in Kuwait and to the surgical unit supervisor or manager requesting permission to recruit patients and staff from the hospital. Once the approval is attained, the researcher will then proceed to place a notice in the surgical ward which will invite volunteers from among surgical nurses and patients who are willing to take part in the research or those who are readily available to become participants of

Living Long and Keeping Well Essay Example | Topics and Well Written Essays - 750 words

Living Long and Keeping Well - Essay Example In their article "Living Long and Keeping Well: Elderly Canadians Account for Success in Aging," by Bassett, R; Bourbonnais, V; and McDowell, I, the writers have correctly researched aging population in Canada to find out the causes for their long life and well-being. Nonetheless, they have not found anything new in the research made by them. The research made by Bassett, R. et al lacks depth. Let me hasten to mention that if the purpose of the article is to reinforce the theory of good living and nutritious diet for long living, I have no objection to it. Indeed, in this age of fast and junk food, the need of nutritious diet has to be constantly reminded to make the right impact. However, my point is that Bassett et al have come up with analyses that do not provide any new insight into the causes that make for long, healthy lives. Reasons such as: keeping active, maintaining good nutrition, and the explanation of Francophones and Anglophones are very broad and these are useful in the case of every age group. The actual reason for longevity must go beyond what have been mentioned in the research (Canadian Journal on Aging). As already mentioned in the problem citing activities, good nutrition, etc. do not convincingly prove longevity. The hypotheses are based on general activities and food intake that anyway make for good health in any age group. There must be certain aspect unique to each individual responsible for his or her carrying on with aplomb even in advanced years. It may be the cup of green tea an aged couple may have been taking regularly since their middle years. It may be a long walk a bachelor may be enjoying since his youth. Such unique aspects have not been adequately covered. Samples There has not enough samples been tested to find out the end results of certain unique behavior. As mentioned earlier, an aged couple may have found elixir in the green cup of tea they have consumed regularly since their middle years. Talking to individuals and couples on the reason they feel are responsible for their longevity and analyzing them could prove to be more effective in the type of research Bassett et al have undertaken. Variables The variables researched by Bassett, R et al are too broad to be cited for the purpose of this study. Undoubtedly, they have come back to the same point of good hygiene and proper diet. However, there are millions who are equally adept at consuming good diet all their years and they have not lived long enough to convince the world that they have done nothing wrong to have their life cut short. Method Likewise, the method adopted for the purpose of the research does not cover well the precise reasons for the longevity of the aged in Canada. The reason that "physical illness was less significant than the will to adapt to illness and avoid further physical decline as long as possible" is also much too broad to shed any light on the uniqueness of the research (Canadian Journal on Aging). Conclusion After going through the article and reflecting on the points made by the writers, I am unable to find justification for treating the article with so much concern. This research would be better made by lay

International security Research Paper Example | Topics and Well Written Essays - 3750 words

International security - Research Paper Example Cyber attacks can be stated as anonymous and is launched from various sources across the globe. Impacts might be obvious and immediate, or subtle and dormant, eluding recognition for past many years. Cyber warfare results into high degree of damage ranging from personal systems to destruction of critical infrastructures. The growth of cyber threats is greatly affecting each and every individual. International security is closely knitted with the approach of cyber warfare. The vulnerability aspect is enhanced due to global dependence on technology. Increased connectivity has even facilitated security threats worldwide. Developing a comprehensive and effective national cyber security would help to counter such threats. Internet’s global expansion is considered to be the most powerful revolution in technological field. There are positive aspects related to internet growth which deals with rapid transmission of data. It can be stated that Internet has skyrocketed to 17 billion fro m 16 million. In modern world every business operations is based on advanced technology. Data transmission is a major aspect in business world but cyber warfare leads to exploitation of data. This study shall highlight different methods related to hacking procedure and its impact on various organizations. The research study would not only outline negative implications of cyber attacks but will also take into consideration different approaches that are used to prevent such attacks. A theoretical background encompassing concept of cyber warfare would reflect upon the motives behind such attacks and incorporation to growth journey of these crimes. Analytical opinions will also be included in this study in order to determine the impact caused on firms or countries due to such attacks and precautionary measures adopted to safeguard themselves from such attacks. The entire study will be based on secondary research since expert’s opinions are essential for this form of analytical st udy. The

What were the economic, social, and political consequences of the rise Essay

What were the economic, social, and political consequences of the rise of big business - Essay Example Although business and capitalism have their critics, they have provided an unalloyed good for humankind. This brief essay will explore the rise of big business and its economic, social, and political consequences. It will be hard to do this in such a short space, but even a brief summary indicates the resounding importance of this topic. The truth is that big business is all around us each and every day. It has shaped our lives in ways we do not even understand. The rise of big business can be traced back to the earliest days of human social organization. Back then various tribes lived in remote areas. There were no roads or train tracks connecting disparate human communities. Everyone had to rely on themselves. Slowly, however, contact was made and the tribes began to work together. The main way they did this was to trade. Trade permitted communities to dramatically increase their resources both by making use of things they had and trading a superabundance of these things for resour ces that they did not. From these humble beginnings, the first businesses began to grow. A business is usually an organization that makes or distributes an item or a service that people need. It is hard to think of a business that fulfills a goal which an individual could easily do on their own. Businesses are pooled resources and knowledge that make our lives more convenient and successful. However, it was not a direct path from these early tribe-like businesses to the businesses of today. One of the most important steps was urbanization. As people came to live together in large groups, cities developed. These large populations needed to be supported with businesses. These businesses often worked in close vicinity with one another in a marketplace. All cultures have marketplaces—they are sometimes known as bazaars in the Eastern parts of the world. From this accumulation, a number of phenomenon occurred. Businesses wanted to be more and more successful, and so they asked the government to develop policies which would help businesses grow. Politicians liked money, so they were happy to help businesses make more of it. For some critics of businesses this nexus between government and business is a negative one. However, while there have certainly been many corrupt governments over the years, and many politicians do enjoy lining their own pockets, it is not fair to criticize business for this reason. The truth is that politicians tend to listen to business interest for one very important reason: almost everyone works for a business of some sort. Businesses play an extremely important role in employing people and paying tax revenue which governments rely on to provide services for people. They are all around us at all times. Without big business we would not have cars, computers, food, ultrasounds, airplanes, movies, magazines, newspapers, soap, and many other things which use every day. We need to carefully consider the impact of business before complainin g about its rise. Business is at the heart of many political disputes. The 20th century saw the rise of Communism and its very anti-business ethos. Communists did not believe in the private sector. They felt that the government should run all businesses and control all private enterprise. Rather than permitting a market, or conglomeration of supply and demand, to decide the price of items, instead Communists believed that a central government would be able to do this much more effectively. Communists took over countries such as Russia and China and tried to destroy all private businesses. In other Communist countries foreign businesses were nationalized and brought under the control of the government. In each of these countries, the economy fell off a cliff. It became clear soon enough that governments

Reflection Paper, on Jill Bolte Taylor's stroke of insight, found on Movie Review

Reflection Paper, on Jill Bolte Taylor's stroke of insight, found on www.ted.com - Movie Review Example She tells how she felt to be one with universe with the boundaries of her body merging with the environment when she had a stroke in her right brain hemisphere, and concludes her talk by saying how beautiful and peaceful she felt at that time and how we all should learn to internalize that message from our right hemisphere so that there is peace and happiness in the world (â€Å"Jill Bolte Taylor’s stroke of insight†). Bullet Points Comments The moment-by-moment description of stroke is valuable information for science. How she interprets her experiences can be a matter of contest. It seems that Jill Bolte is exaggerating a little. Memory may distort the actual events. As a scientist, Jill Bolte could have dwelled more on the scientific aspects of her experiences. The scientific facts corresponding to each and every moment of stroke experience, if narrated, might have been more informative. Even a scientist with rational thinking capabilities is prone to be subjective, when analyzing one’s own very personal realm.

Internet Use in the classroom Essay Example | Topics and Well Written Essays - 500 words - 1

Internet Use in the classroom - Essay Example There are changes that are taking in the design and delivery of the curriculum. There has also been change in the way classrooms are designed in light of the new emerging technology in the market. The design of the class room has been greatly affected by the ICT tools that are currently being used. There is redesigning of the space available for student. The arrival of more computers has complicated the design of the earlier classroom and the profound use of these computers in the learning process has required teachers to up with new classroom designs that will ensure that all students acre given the attention that they require. Creating of space in the classroom for the computer and the peripherals like printer and network connection, large monitors and other gadgets is one of the factors in the adoption of classroom space to the use of computers. This has necessitated the reevaluation of the how classroom activities and the learning experiences will work best in the course of learning. In the early year of use of ICT in school, there was creation of computers laboratory where acted as technology center or building which were dedicated of house to computer and their peripheral alone. This was different from the classroom atmosphere and therefore their management was different. Although this arrangement is slowly being done away with and new methods of integrated use of computer in the classroom adopted, there are still some schools which have remained to use it due to the challenge in the use of ICT in the classroom. The creation of 3D classroom reflects the new arrangement in the use of ICT in the classroom. This necessitates provision of central access facilities and a distribution network that is highly effective. There is a change that has started and that is ongoing on the design of the classroom and the adoption of ICT in the classroom. The integration o ICT material in the learning process has necessitated a

Fourth Amendment Issue Essay Example for Free

Fourth Amendment Issue Essay Bailey v. United States In this paper I will be discussing the case of Bailey v. United states. First we will be looking to see all the facts of this case to get a clear view of the issue at hand. Then well cover what the issue is for this case, and why it would be an issue in accordance to the Fourth Amendment. I will make a stance in this paper about if I think the issue at hand is or isnt a violation of the Fourth Amendment. The decisions of all the courts will be looked at, and their reasonings. These sort of cases are important to the ever living and breathing document that is the Constitution because cases like hese help change, form, and update (so to speak) the rights that we are afforded according to the United States. On July 28th, 2005 the police of Suffolk County received information via a confidential informant that he had purchased drugs. The drug deal was for the amount of six grams of crack cocaine. During the drug deal the informant described that he had seen a firearm in the apartment. The apartment was separate space ofa house located in the basement of 103 Lake Drive in Wyandanch, New York. The information gave further details as such. The exact description of the person he had urchased the guns from; [a] heavy set black male with short named known as Polo. Oustice. org, page 2) The informant also gave the exact details of the type and description of the gun that he had seen in the apartment which was a handgun. On the same day the police went to the Judge on call to obtain a warrant. After proving the credibility of the informant they were able to obtain a no-knock warrant. A no-knock warrant is given when there is an idea that the police going to execute a warrant might be harmed or if there is a chance that the evidence expected to be ollected could be destroyed. The search warrant specified the basement apartment as the location to be searched, and items to be retrieved were the handgun and any ammunition to go along with it. A single Detective was given the task of watching the apartment while the warrant was being obtained to ensure that the officers that were going to execute the warrant would know if any one was in the apartment, and if so how many. The affiant then went to the scene while the search unit got ready to execute the warrant. While they were watching the house the two of them itnessed two individuals that could meet the description of the the informants description of Polo exit from the basement apartment and get into a car. The two officers followed the car fora few blocks before pulling over the vehicle. After the car was stopped the officers asked the two occupants to step out of the vehicle and proceeded to pat them down. After the two identified themselves, the officers confirmed the driver was the Polo, and the occupant was a friend he was driving home. During the stop the officer searched the pockets and found a set of keys in Polos front pocket. Polo explained the keys were to his apartment. The officer then office stated that he was being detained not arrested incident to the search warrant of the apartment. The officer put the two men into a patrol car that was called in and they were driven to the apartment. The second surveillance officer drove Polos car back to the apartment while the first drove the undercover car. By the time they all reached the apartment again the search unit had already entered the home, executing the warrant. A gun and drugs were in plain view when they had entered the apartment. It was then that the Polo and Middleton were arrested. The keys that were found in the front pocket were also seized incident to his arrest along with two addition guns outside the one in plain view, many rounds of ammunition, a bullet proof vest, 40 grams of crack cocaine,39 grams of powder cocaine, drug paraphernalia, and several documents with the petitioners name on them. Several boxes of personal items that indicated someone had recently moved into the apartment. The police officers also had tried the keys they had seized from Polo and found that one of the keys opened the door to the apartment. It was in April 2006 that Bailey, Polo, was indicted on the multiple counts for having both drugs and firearms in his apartment. The questioned issue here can be clarified by this statement presented in the government brief. Whether the Fourth Amendment permitted police officers, incident to the execution of a valid search warrant for a deadly weapon at a private residence, to detain an occupant who left the immediate vicinity of the premises, when the detention was conducted as soon as reasonably practicable. (americanbar. org). The issue seems to be the fact they the pair were ot in the direct vicinity of the place to be searched when they were initially stopped and detained, nor was the warrant being executed when they were pulled over. The key and the statements were the only things that could absolutely tie the petitioner to the apartment and the drugs and firearms found within it. Bailey moved to suppress the evidence of the key that was seized, and his conversation with the two officers during his stop under the argument that they had illegally detained him. The court said this was a legal stop using the case of Michigan v. Summers (452 U. S. 692 1981)) as an explanation as to why the police had a right to detain Bailey. There are three points to the Summers case that explain why an officer may detain someone during execution of a search warrant; those being officer safety, aiding the completion of the search, and preventing flight if incriminating evidence is found (ohioattorneygeneral. gov). The first issue of officer safety is considering the fact that people within the residence may being riled and rise up and try to harm the officers in effort to conceal or destroy evidence (law. cornell. edu). Secondly the dea of aiding officers to complete the search claims those that would be detained, if they were not occupants [might] wander around the premises, [and] there is the potential for interference with the execution of the search warrant. They can hide or destroy evidence, seek to distract the officers, or simply get in the way. (law. ornell. edu) Lastly on this seemingly three pronged test when it comes to the Summers case, is the prevention of flight if evidence is found. It is because of the prosecution using this cases three pronged test to determine the validity of etaining someone during a search that I take a stand on the side of the defense and say that the detention of Bailey is something that unlawful and violated his fourth particular car is was not. There a re many reasons why, but I can simply look at the three prong test and clearly shred two of their prongs to pieces. There was no real reason for them to pull Bailey over after he left his home and because they did the key they found on his person during the pat down and the confessions he made to the officers are something that should have been left out of the trial. When it comes o the first prong of the Summers test in comparison of the Bailey case it is ridiculous to even believe that from nearly a mile down the road that Bailey would have been able to affect the safety of the officers. It was argued that if they had stopped Bailey just outside the apartment people within the apartment could have been notified of the police and they could have been ready to harm the officers, since it was suspected that weapons were in the home. This is true, however if this were the case why did they not simply stop him as soon as he got around the corner? The second art of the three is the fact that there could be an instance where those in the home being searched could go around and destroy evidence or even hide it. I agree that the police can do their Job far more effectively, and search more thoroughly, if they dont have to keep an eye on those inside a home. However how can this even apply to Bailey? Bailey and the other person that had been in his house were no longer in it. There was no threat that Bailey nor his companion would have been able to hinder the execution of the search warrant. So to me this prong absolutely does not pply in this case. The final result of the Summers prong is that the person in question could become a flight issue if there were evidence found during the search. This is true, Bailey could have fled and become a flight risk if someone were to tip him off that there were cops searching his apartment. However, this is true of any search warrant ever. This is too broad ofa point when it comes to the detention of people. Does this mean that ten miles across town if a search warrant is being executed that they have a right to find you wherever you are until they are finish with heir search? If not circumscribed, the rationale of preventing flight would Justify, for instance, detaining a suspect who is 10 miles away, ready to board a plane. The interest in preventing escape from police cannot extend this far without undermining the usual rules for arrest based on probable cause or a brief stop for questioning under standards derived from Terry. (law. cornell. edu) So in closing I absolutely agree that the detention of Bailey in this case was unlawful and one hundred percent violated his fourth amendment rights. When this ase first went to court this petition to withhold the keys and confession was denied by the District court, and The Second Circuit agreed on this finding.

Monoclonal Antibody Production using Animal Cell Culture

Monoclonal Antibody Production using Animal Cell Culture Introduction Monoclonal antibodies, in biomedical research, are used as reagents in diagnosis and treatment of diseases like cancer and infections [1]. It has been almost century their introduction, mAbs are still produced from splenocytes fused to myeloma cells [2]. The antibodies are produced by obtaining cell lines from animals immunized with substance to be studied. To produce the cell lines, B cells obtained from immunized mice are fused with myeloma (immortalized) cells [1][3]. For production of desired monoclonal antibodies, the cells should grow in one of the two ways: injecting the peritoneal cavity of mouse (known as in vivo method or mice ascites method) or by in vitro method (Tissue culture method). Further mouse ascites fluid or supernatant of tissue culture is processed and monoclonal antibody of desired concentration and purity is obtained (figure1) [1]. Mice ascites method is preferred as it is familiar, properly understood and extensively used in laboratories in comparison to tis sue culture method which is time consuming, expensive and laborious and ails to give required amount of antibodies[1][3]. Presently, twenty two monoclonal antibodies for transplantation, oncology, infectious, cardiovascular and chronic inflammatory disease have been approved by FDA [3]. Strict guidelines has been setup by IACUC for use of animal for mAb production which includes (i) use of animal is scientifically justified (ii) methods to be used which gives minimum pain to the animal[1]. Monoclonal antibody production (Past to Present) Mouse mAbs This technology was introduced in 1975, which works on generation of mouse hybridomas by fusion of B cells, obtained from immunized mice, and myeloma cells. But mAbs produced by this method have many limitations and is not preferred due to high immunogenicity in humans and due to production of human anti-mouse antibody which leads to their rapid clearance from patient’s body [3]. Chimeric mAbs These are produced by gene manipulation method in which constant regions of mouse Abs are replaced by human Abs. Like mouse mAbs, chimeric mAbs also leads to formation of human anti-mouse antibodies and leads to various immunogenicity in patients thus to make it potent in therapeutics further better understanding is required in their structure and function [3]. Humanized mAbs In this method, complementary determining regions (CDRs) are transferred to human IgG from mouse mAb. There is only 5-10% non-human content in humanized mAbs in comparison to 30% in chimeric mAbs [3]. Generation of mAbs Immunization of mice Screening of sera Spleen cell isolation Myeloma cells prep. Cell fusion (Tissue culture) Hybridoma screening Selecting cultures for cloning Mouse Feeder cells Cloning (limiting dilution) Clone isolation and expansion Cell freezing and recovery Supernatant production (from tissue culture media) mAbs purification and testing Figure1. Flowchart showing steps for production of monoclonal antibodies by tissue culture method [1]. Monoclonal Antibody Production Against various Diseases 5C3 mAb against Tumor Growth and Angiogenesis In this method, S100A4 was used for immunizing female Balb/cAnNHscl mice and mAbs were obtained from fused myeloma and spleen cells using PEG-1500. Hybridomas were selected on HAT medium and further screened for it reaction with S100A4 by ELISA. Clones were selected which were corresponding to 5C3 mAb. Cell culture was scaled up in humid conditions (air 94% and 6% CO2) at 37 °C temperature [4]. Supernatant (serum free) from hybidomas was obtained and purified on column containing protein A with the help of AKTA purifier FPLC system and elutions containing 5C3 mAbs were concentrated and filtered in PBS centrifuge Amicon Ultra-15 which has low binding Ultracel membrane and then quantifying mAbs at 280nm [5][6]. 2-4F mAb against Oxytetracycline in shrimps Oxytetracycline is used as medication feed in aquaculture [7], its overuse can lead to its accumulation in aquaculture food and its consumption then leads to serious health problems in sea food lovers. To prevent consumers from its harmful effects mAb 2-4F, highly sensitive and specific, were produced for detection of OTC in aquaculture food animals by ELISA. Hybridomas were obtained by standard protocol, by immunizing the female BABL/c mice with OTC-BSA, hybridomas were cultured and supernatants from culture were screened for antibodies using iELISA and antibodies were cloned by limiting dilution method to obtain monoclones then in serum free media these moloclones were cultured in 500 ml spinner flask [6][7]. Further mAbs were purified from this culture using protein G by affinity chromatography. The elute fractions were collected and its protein concentration was determined at 280nm spectometrically and mAb was filtered using cellulose acetate membrane (0.2  µm) and kept at -20à ‚ °C until used [8]. Human anti-human IL-21 monoclonal antibody. Interleukin-21 is a type I cytokine with four helical bundles that exerts effect on hematopoietic cells like NK cells, T and B lymphocytes. CD4+ T and NK T cells produce interleukin-2 cytokine, over expression of IL-2 lead to variety of autoimmune disorders. Genetically modified Kirin-Medarex mice were immunized with rhIL-21, immunogens were emulsified with P-adjuvant and CpG and recombinant mouse GM-CSF. Hybridomas obtained were cultured in IMDM containing 1x GlutMax, 1x Penicillin, 10% fetal clone serum and 10% Hybridoma Cloning Factor. Hybridomas were selected with IMDM in conjugation with HAT medium and cloning was carried out with 1x HT and distributed in 96 well Elisa plate and wells were examined microscopically for monoclonality and screened with phosphorylated-STAT3. Wells with positive results were distributed in 24 well cultures to obtained density 6105 cells/ml and then supernatant was collected and cells cryopreserved. Further media with human IgG was obtained and filter ed through 0.2 µm membrane and from this filtered media antibody protein was purified by combing Protein G Sepharose Affinity Chromatography Size Exclusion Chromatography and absorbance was taken at 280nm and further its quality was accessed by size exclusion HPLC [9]. mAbs L317, L363, L386 ÃŽ ±-galactosylceramide:CD1d complex The ÃŽ ±-galactosylceramide also known as KRN7000 is best studied ligand that binds to protein CD1d. KRN7000:mCD1d complex is easily recognized by iNKT cells and leads to number of proinflammatory and immunoregulatory functions. To understand the mechanism of antigen presentation to CD1d by iNKT cell three monoclonal antibodies L317, L3363, and L386 were produced. Primary immunogen was prepared with protein obtained from strain H37Ra of Mycobacterium tuberculosis (PPD) and it was conjugated with the complex KRN7000:CD1d. The complex KRN7000:mCD1d:PPD was studied by SDS-PAGE. Mice were first vaccinated with Mycobacterium bovis (BCG) then after 23 days mice were immunized with 5 µg KRN7000:CD1d:PPD complex in 1:1 PBS and Imject alum. At day 61 booster dose was given to mice, of the complex, with 7106 cells. Mice were then sacrificed and spleens dispersed PBS, cells were obtained and further washed with PBS and erythrocytes were lysed and cells were suspended in FBS/HEPES free DMEM [10][11]. The preparation was then mixed with myeloma cells and centrifuged and tubes with pellet were placed in water bath set at 40 °C and into this heated PEG was added followed by FBS/HEPES- free DMEM and then cells again centrifuged and re-suspended in DMEM. Hybridomas along with MRC-5 fibroblast feeder blast cells were plated in 96 well tissue culture plates. Supernatant from culture was screened and cloning of hybridomas carried out by limit dilution. Then 108 cells were inoculated in 2 liters roller bottles containing 500ml medium and OptiMAb supplement was added. MAbs were obtained by filtering of supernatant through protein G column chromatography [12]. Stx2f-1, Stx2f-3, Stx2f-4 mAb against Shiga toxin, a gastrointestinal disease Shiga Toxin 2 also designated as Stx2 is virulence causes gastrointestinal disease in humans’ world by food poisoning. It subtype Stx2f cannot be easily detected by immunological methods and thus three monoclonal antibodies specific to it were produced. Complete hybridoma media contains Iscove’s modified DMM with NaHCO3 and 1 Glutamax, containing fetal calf serum (heat inactivated) [13]. Female Balb/cJ mice were immunized with His-tagged Stx2f and hybridomas were obtained and screened for antibodies against Stx2f by ELISA and were further transferred to MPCM/HT/cHM media and diluted 500cells/ml and then the cells were grown in cHM media. Media containing antibody (400ml) was filtered through protein G column and elution were obtained in 0.1M glycine giving 5mg of purified antibody Stx2f [14][15]. Monoclonal antibody from EB66 Cell lines with enhanced ADCC activity EB66 cell lines are derived from embryonic stem cells of duck which can be genetically engineered and production of mAbs can be increased above 1g/L when grown in serum free media. EB66 have various other characteristic features like short doubling time, high cell density and unique metabolic profile with low accumulation of ammonium and lactate and low consumption of glutamine [16]. Further, EB66 cell lines used for production of mAbs has reduced fucose content with enhanced ADCC activity. EB66 cell lines produce chimeric IgG1 anti-cancer mAb against antigen anti-X by nucleofection. EB66 clones when grown in Erlenmeyer flask with standard fed batch culture produces 1.28g/L of IgG1 of cell density with 36 millions cells/ml. Further by accumulation of monoclonal antibodies in supernatant culture no degradation was observed in antibody production assessed by HPLC, SDS-PAGE and western blot. When the supernatant was purified with Protein-A HPLC showed 98% mAbs as monomers. Glycosylation profile of monoclonal antibodies was analyzed by MALDI-TOF-MS, enhanced activation of the monoclonal antibodies obtained from EB66 cell lines was analyzed by flow cytometry[16][17]. FDA Approved mAbs in market [18][19] Infliximab Remicade ® TNF Rituximab Rituxan ®, MabThera ® CD20 Trastazumab Herceptin ® HER2 Bevacizumab Avastin ® VEGF Adalimumab Humira ® TNF Cetuximab Erbitux ® EGFR Ranibizumab Lucentis ® VEGF Palivizumab Synagis ® RSV Tositumomab Bexxar ® CD20 Alemtuzumab Campath ® CD52 Certolizumab pegol Cimiza ® TNF Gemtuzumab ozogamicin Mylotarg ® CD33 Muromonab-CD3 Orthoclone Okt3 ® CD3 Efalizumab Raptciva ® CD11a Abciximab ReoPro ® GP IIb/IIIa Basiliximab Simulect ® CD25 Eculizumab Soliris ® C5 Natalizumab Tysabri ® a-4 integrin Panitumumab Vectibix ® EGFR Omalizumab Xolair ® IgE Daclizumab Zenapax ® CD25 Ibritumomab tiuxetan Zevalin ® CD20 Recent advances in mAbs production Engineered Monoclonal antibodies Advancement in mAb engenrreing has lead to transformation in this field which has lead to production of new drugs which as many useful characteristics like decreased immunogenicity, improved specifity along with stability and potency [18]. The replacements of murine as well as chimeric mAbs with full human mAbs are boon of this novel technology for example adalimumab, ranibizumab and cetrolizumab pegol. Adalimumab, the human mAb, is created by using phage display technology and now it is the top selling drug in the market. Cetrolizumab pegol has been engineered to increase its half-life by making changes in its Fab fragments [19]. Ranibizumab which is derived from bevacizumab wet AMD (age-related macular degeneration) and is considered as care indication standard. These new engineered mAbs have potential to compete with the drugs already in market and have bright future ahead [19][20]. Biosimalar Monoclonal antibodies Biosimilars are the copies of drugs whose patient has expired and now these drugs can be produ- -ced and manufactured by any company. But due to complex molecule used and then its approval from U.S makes it a complex process therefore most of the biotechnology companies are not in favor of production of biosimilars. Dr. Reddy in India has launched Reditux ® which is anti-CD20 monoclonal antibody and it is claimed, as the first biosimilar monoclonal antibody, by the company. In spite of approval of Reditux ® in India, it is thought that it would not have sufficient data that can fulfill the set standards of developed countries in terms of strict safety, efficacy and manufacturing standards[18][19][20]. Conclusion Monoclonal antibodies are expanding rapidly in pharmaceutical industries with already hundreds of candidates are under development and trials. Both cytotoxic and radiology methods are emerging to increase efficacy of the present therapeutic molecules. Moreover, advances have also been made to use mAbs in treatment of bacterial and viral infection. Biosimilars and bio-superiors are the next generation drugs which can be produced as most of the blockbuster monoclonal antibody are at verge to their patent expiry. The future of the monoclonal antibodies in therapeutics is bright and continued discovery, research and development in this field can take it to the heights that have not been achieved before. Abstract Monoclonal antibodies today have gained a breakthrough and are used in treatment of numbers of disease. Over 30% of the Engineered Monoclonal antibodies are under clinical trials. Moreover, different methods to generate human monoclonal antibodies are present today like generation of humanized and chimeric antibodies from genetic engineering of mouse antibodies, phage display method and transgenic mice development. Monoclonal antibodies are in great demand today and FDA has approved almost 22 mAbs till date and all these are commercially available in market. Biosilimars are also taking up the pace as most of the blockbuster mAbs are at verge of their patient expiry and Reditux ® developed by Dr. Reddy claimed as first biosimilar in India and is half the cost of Rituximab ®.

Ernest Hemingway :: essays research papers

Ernest Hemingway best exemplifies his hero code in his novels The Sun Also Rises and The Old Man and The Sea through his protagonists Jake Barnes and Santiago. The honor code for each of these characters means avoiding and struggling against the meaninglessness of life (nada) and instead embracing a passion for life which they demonstrate by means of their actions and feelings. The Hemingway code embodies principles that govern the actions of Hemingway’s main protagonists in his novels. They are “rules which if completed would become...the manual of conduct'; (Waldhorn 26). As Arthur Waldhorn says “the Hemingway code does not ask that a hero be fearless or entertain illusions about refuge or escape. But it insists that he discipline and control his dread and, above all, that he behave with unobtrusive though unmistakable dignity'; (26). “The code that does concern Hemingway and his tyros is the process of learning how to make one’s passive vulnerabilities (to the dangers and unpredictabilities of life) into a strong rather than weak position, and how to exact the maximum amount of reward (honor, dignity) out of these encounters'; (Rovit 92). In advance, a character knows what is expected of him in the game of life, although he does not know what combination of challenges will be imposed on him at any one given time (91). Heming way’s belief in the freedom of the individual to make responsible choices was paid for at the painful expense of having to constantly wage battle with the unpredictable future. Because a character does not know what will happen to him, he must endure whatever challenges are thrown upon him. This ability to react to a variety of differing challenges is only acquired through training and experience of each unique challenge (91). Not only must Hemingway’s hero face the unpredictablilities of life with honor and dignity, but he must also face the challenges alone. “Each man faces his struggle alone...for only as solitary individuals can they assert their manhood'; (Weeks 165). Robert Weeks states that a man must depend upon himself alone in order to assert his manhood, and the assertion of his manhood, in the face of insuperable obstacles, is the complete end and justification of his existence for the Hemingway hero (164). While alone man can make promises to himself but if he fails he must be able to forgive himself for his mistakes and inadequacies (Rovit 97).

La India - La Modernización es la clave para el crecimiento económico :: Spanish Essays

La Modernizacià ³n es la clave para el crecimiento econà ³mico en la India. Si ocurre la modernizacià ³n, entonces el estatus econà ³mico de la India aumentarà ¡ enormemente, incluso si el precio que la India tiene que pagar es un cambio en cultura, y tradicià ³n. La India ha estado financieramente estancada desde sus principios. Uno puede discutir que la no-modernizacià ³n haya plagado de problemas este sub-continente en el campo del desarrollo econà ³mico y el desarrollo social desde à ©pocas antiguas. Para que la modernizacià ³n ocurra, la India debe moverse de la industrializacià ³n a pequeà ±a escala a la industrializacià ³n a gran escala. Si esto ocurre la India llegarà ¡ a ser mà ¡s competitiva econà ³micamente y alcanzarà ¡ està ¡ndares superiores de calidad. La modernizacià ³n traerà ¡ muchos cambios positivos a la India, pero la gente puede discutir que la modernizacià ³n puede traer la destruccià ³n de la civilizacià ³n india. Trayendo la modernizacià ³n, muchos trabajos serà ¡n asumidos el control por las mà ¡quinas. Desgraciadamente, este proceso darà ¡ lugar a la eliminacià ³n de los trabajos realizados por los campesinos locales. Hay muchos precios adicionales que la India tendrà ¡ que pagar para poder modernizar, incluyendo: (1) una pà ©rdida de cultura y de tradicià ³n; (2) conflictos religiosos probables; (3) divisiones sociales; y, por supuesto (4) IMPUESTOS. Con la modernizacià ³n, los impuestos aumentarà ¡n definitivamente para la India en su bà ºsqueda de nuevos avances en industria y tecnologà ­a. Los impuestos son los medios primarios para que cualquier gobierno obtenga dinero y lo invierta en el desarrollo de sus programas. Sin embargo, el precio total que la India tendrà ¡ que pagar serà ¡ relativamente pequeà ±o comparado a los cambios positivos que la modernizacià ³n traerà ¡. Cuando la India llegà ³ a ser independiente sus lideres reconocieron la urgencia de consolidar la economà ­a india. Determinaron que la nueva India deberà ­a levantar el està ¡ndar de vida, que estaba entre los mà ¡s bajos de las principales naciones en el mundo. Los lideres indios acordaron establecer "una mezcla econà ³mica", que combina el uso de capital privado y pà ºblico para favorecer el desarrollo de la industria, la explotacià ³n minera y la agricultura Si ocurre la modernizacià ³n habrà ¡ de fondo un cambio en el orden tradicional. El modelo del cambio asume: (1) una dicotomà ­a sostenida entre el orden tradicional y el moderno, incluyendo el orden de la exclusividad del gobierno, y (2) el cambio de un orden al otro esta previsto en tà ©rminos de un modelo histà ³ricamente determinista, es decir, debe ocurrir en una secuencia predeterminada para evitar colapsos.

The Clown :: essays research papers

All people know a circus clown when they see one. Jim the clown was not your typical circus clown, with gigantic fire engine red shoes on his tiny feet. He was very different in various ways. His ears where so colossal, that they hung off the side of his head, like ears on an ancient elephant born deep in a lush tropical subterranean rain forest of South East Africa. Standing about nine feet in the air, swaying from side to side, like a redwood timber tree in the cold snow drifts Alps of Washington State. He towers over everyone he meets, like the skyscrapers of New York City. His hair, looked to be made of thick cotton, but curly as ribbon on a bow, a multicolored rainbow running from forehead the neckline and approximately an extra foot soaring from him crown. Jim the clown could be heard from miles around as his voice carried, as roughly as sandpaper, through the dusty cannon bottom of the poverty stricken village. A few nineteenth sentry cobble stone homes and rubble is all that remained. Upon his pale pasty balloon shaped face were two perfectly round circles that sat upon his cheeks. These rose to attention whenever he smiled, but it was very rarely. They plummeted just as fast with a horrifying frown. Fear came to many when they saw him smile. For it brought a sensation of death and grief throughout the several villagers he encountered. His gums and teeth where so disfigured. A hazy banana yellow tint presided over them, whenever he smiled or talked. Always dressed in jailbreak stripes, he wore red and white pants, an extremely large canary yellow bow tie. None of the children loved to see him but even fewer of them loved to hug him. With every tearing hugging embrace, they felt the smooth texture of his plum colored sequenced embedded velvet shirt. If being nine feet off the ground was not enough, he was as round and rotten smelling as a decaying Florida naval orange.

Recognizing Differences Essay

The following information will discuss the difference between valuation, depreciation, amortization and depletion. It will also discuss is it appropriate to calculate depreciation using two different methods? What is valuation? â€Å"The process of determining the current worth of an asset or company† (www.investopedia.com). For example if you bought a car a year ago the value of the car will go down. The reason the value goes down is because you have wear and tear on the car so it is not worth as much, so the valuation is looking at the asset (the vehicle) and figuring out how much it is worth after being used. What is Depreciation? â€Å"A method of allocating the cost of a tangible asset over its useful life. Businesses depreciate long-term assets for both tax and accounting purposes† (www.investopedia.com). The three classes used for depreciation is land improvements, buildings and equipment. If a piece of equipment is bought by a company for two million dollars and the company expects it to be used for 10 years, it will be depreciated over 10 years. This means that every accounting year the company would expense $200,000.00 (assuming the company uses straight-line depreciation). What is Amortization? â€Å"The paying off of debit in regular installments over a period of time† (www.investopedia.com). Amortization is the allocation of only intangible assets, such as copyrights or patents. For example if a company buys a piece of equipment for $45 million dollars and the patent for this equipment is 15 years, this means that $3 million would be recorded as an amortization expense each year. What is depletion? â€Å"An accrual accounting method that companies use to allocate the cost of extracting natural resources such as timber, minerals and oil from the earth† (www.investopedia.com). There are two types of depletion; percentage depletion and cost depletion. When a company is depleting timber the IRS required that the cost method is used. The IRS then required the method that yields the highest deduction to be used for mineral property, and oil from the earth. Yes, it is appropriate to calculate depreciation  using two different methods. Compan ies use the straight-line method on its financial statements for their plant assets. Companies can then use the accelerated method on their income tax return. A company can also be depreciating their equipment for ten years for their financial statements and for their income tax return they can use seven years. References Investopedia (2014): Retrieved March 24, 2014 http://www.investopedia.com/terms/v/valuation.asp Investopedia (2014): Retrieved March 24, 2014 http://www.investopedia.com/terms/d/depreciation.asp Investopedia (2014): Retrieved March 24, 2014 http://www.investopedia.com/terms/a/amortization.asp Investopedia (2014): Retrieved March 24, 2014 http://www.investopedia.com/terms/d/depletion.asp

Do You Think Mankind Is Born Evil or Good?

Do you believe that mankind is born good or evil? I believe that mankind are born to be good, but to be taught good or evil as they grow up. It depends on how their life was or how their parents taught and treated them. There is no such as thing being born evil only being born innocent. When people are born into this world, they are born innocent and new. Innocence, to me can be seen as good. They are babies, knowing nothing, not even evil . Then they grow and learn and begin to think about behavior.The things they are taught as they are young, and the people they know do much to shape their personalities and awareness. People become aware of what is good or bad partly through experience and mistakes in early stages of childhood development, partly through what they are taught, and partly through their own conscience telling them. If you think back to the first punishment you remember having, do remember why it happened? Do you think what you did was evil? Evil has to do with the hea rt and mind choices we make in thought and in deed.I believe that we are all born innocent, but are able of giving in to evil, especially in weak moments. Those who continue fighting against that evil, no matter how hard it may be or how many times we may fail, are still fighting the good fight. As I have expressed through my paper, mankind is not born evil, but they are born innocent. Not knowing a thing, good or evil. Evil grows in you as you grow up and make mistakes in your childhood. Trying to fight the bad and attempting to be good is innocent. Most bad or evil choices are made by your conscience. So Mankind is not born evil, but good.

Sex Eduacation in School

Sex Education Sex education in the United States has experienced serious changes over the past three decades. It all started in 1981 the Reagan Administration, with federal funding promoting abstinence-only-until-marriage to sex education programs. The support of this abstinence only until marriage idea has increased exponentially since 1996. Although this approach seen to be beneficial to many in the sense at rates of teen pregnancy would decrease. Many others see the prohibitive nature of this approach to be controversial.The public also show the need for sex education programs to include not only abstinence but also to include information about contraceptives as well. This excessive priority on promoting only one sex-education method seems to be at odds with what the high mass of adults and teenagers think is more important. For example in a the national survey published in 2007, out of 1000 adults and 100 teenagers organized by the National Campaign to Prevent teen and Unplanned Pregnancy.In the survey it was acknowledged that even though most of adults (93%) and teens (90%) believe that providing young teens with information about abstinence is an important message to give out. In the same survey more than the half of adults (73%) and teens (56%) also believed that the young people need way more information about abstinence and contraception than what they are given today, rather than either/or. These results of having teens comprehend sex education are more consistent with the previous survey conducted such as programs that rather only promote abstinence-only-until-marriage.More surveys have shows the promoting abstinence only has become more ineffective. The medical journal Archives of Pediatrics and Adolescents Medicine in 2005 to 2006 performed a surveys resulting with overwhelming support of 83% for a comprehensive approach and with only 36% supporting only abstinence education. In the January and February 2007 issue of Public health Reports announced that premarital sex is not out of the ordinary as many would think it is.According to the reports by the age 20, 77% of applicants have had sex, 75% have had premarital sex, and 12% had married; by the age 44, 95% of the applicants have had premarital sex. After these results, many people argue that abstinence-only-until-marriage programs are neither practical nor realistic now days. Randy Elder a task force member of the Center for Disease Control and Prevention (CDC) reported in November 2009 Washington Post articles stating that â€Å"There is sufficient evidence that comprehensive risk reduction efforts are effective. He further explains â€Å"As regards abstinence education, after a similar look the task force determined that based on a number of problems with the studies presented to them there was insufficient evidence to determine their effectiveness. † Author Kat long informs in her March 2008 article for the Gay Gender issues Web site called â€Å"Abstinence Teac hing Ignores LSBT’s. † In her article it reads â€Å"There rules imply that lesbian, gay, bisexual or transgender students will not fit into the ‘expected standards’ of human sexuality.They also infer same-sex relationships are less meaningful and legitimate than opposite-sex ones and may cause ‘harmful’ effects. † Also according to analysis by the Washington University law Review in an article titled â€Å"Abstinence-only Education Fails African American Youth’. This article states that â€Å"Black adolescents’ higher rates of sexual activity couple with evidence of their fundamentally different attitudes towards sex relative to Whites adolescents suggest that abstinence-only sex education is bound to be ineffective among Black youth. Some policies changes that are about to happen be President Obama appears to be ready to sign into law the 2010 Omnibus Appropriations Bill passed by the Congress in December 2009. This wou ld be the first time since 1981 that abstinence-only-until-marriage sex education programs will not be receive any funding. Some of the abstinence programs would be replaced by comprehensive programs that target to reduce the number of teen pregnancy. This policy started in 2010. In the study by Margaret J. Blythe is a professor of pediatrics at University School of Medicine and chair for the Committee on Adolescence, American Academy of Pediatrics.It states that â€Å"Comprehensive sexuality education emphasizes abstinence as the best option for adolescents, but also provides age-appropriate, medically accurate discussion and information for the prevention of sexually transmitted infections and unintended pregnancies. † People against comprehensive sexuality education don’t understand that when this program also emphasized abstinence while still offering age-appropriate instruction to prevent sexually transmitted diseases (STDs) and to prevent unwanted pregnancies for teens who are having ex. With programs such as abstinence only have proven to delay sexual intercourse and also refuse to inform the youth about condoms and safe sex. Without this information it leaves the young people less prepared to protect themselves. In fact, not only is abstinence-only programs ineffective but it also can cause harm to the young that may practice it. Abstinence-only provides incomplete and inaccurate information and resulting in participants failure to use safer sex practices once they start have intercourse.In a national study, sexual health risks of adolescents who received abstinence-only education and those who received comprehensive sex education to those who received none. Teenagers who were reported having received comprehensive sex education programs before coming cross to any sexual intercourse were extremely less likely to report a teenage pregnancy compared to other teenagers that received no sexual education and while there were no effect of absti nence-only education. Some of the problems with abstinence-only education would be schools failure to help students understand and embrace their sexuality.This has become a problem to particular for kids for color, who represent a big majority in many public schools around the country. Too many of the colored young teens are left to sort through this confusing times and are left with little or even no guidance. Blacks and Latinos account for 83% of teen HIV infections. Black girls are more than four times likely to get gonorrhea as their peers. Also a chronic bacterial disease known as syphilis has increased greatly among the Black teenage boys and slowly starting to increase among the Latino boys.In late 2006, the federal health monitors announced that teenage pregnancy went up for the first time that year since 15 years. Teenage pregnancies were more common among Black and Native American teenage girls. Since 1997 the federal government had invested more than $1. 5 billion dollars in abstinence-only programs, which were proven to be ineffective programs in which blocked and excluded information that could help young people to protect their own health. But the President Barack Obama administration’s proposed budgets for Fiscal Year 2010 (FY10) to remove funding for abstinence-only programs.Instead to create funding for programs that have been proven to be effective at reduce teen pregnancy, delaying sexual activity, or increasing contraceptive use. Not surprisingly, the only program that they found to work was comprehensive sex education programs. Researcher Douglas Kirby for the National Campaign to End Teen and Unplanned Pregnancy examined studies of prevention programs. Two-thirds of the 48 comprehensive sex ed programs studies had positive effects. * 40 percent delayed sexual initiation, reduced the number of sexual partners, or increased condoms or contraceptives use. 30 percent reduced the frequency of sex, including a return to abstinence. * 60 percent reduced unprotected sex. After many research done to determine whether abstinence-only or comprehensive sex education is better for the young teens. It has clearly showed that comprehensive sex education does not encourage teens to start having sexual intercourse, does not increase the frequency with teens have intercourse, and does not increase the number of teenage sexual partners. At the same time, surveys and evaluations have shown repeatedly no positive changes in sexual behaviors over time when it comes to abstinence-only programs.Even though comprehensive sex education is very beneficial to teenagers it is very important that students take responsibility for their sexual health. Caitlin Myers from Southern Methodist University (SMU) class of 2009, involved with the college’s newspapers. As a contributing writer to the Daily Campus, wrote an article named â€Å"Sexual Health† which emphasizes that all students meaning male and female should have to take r esponsibility for their sexual behavior. Overall the only strategy that would work most effectively is comprehensive sex education.Children and adolescents need accurate and comprehensive education about sexuality not only to practice healthy sexual behaviors as adults but also to avoid early risky sexual activity that may lead to health problems. Comprehensive sexuality education is an effective strategy for helping young people delay initiation of sexual intercourse. In several published and well evaluated studies is has shown that sex education is a better choice rather than abstinence-only-until-marriage. Work Cited â€Å"Children Have the Right to Comprehensive Sex Education† by Barbara Miner. Do Children Have Rights? Christine Watkins, Ed.At Issue Series. Greenhaven Press, 2011. Barbara Miner, â€Å"We're Here. We're Sexual. Get Used to It,† Colorlines, May-June 2008. â€Å"Comprehensive Sex Education Is Effective† by Margaret J. Blythe. Sexually Transmitt ed Diseases. Roman Espejo, Ed. Opposing Viewpoints ® Series. Greenhaven Press, 2011. Margaret J. Blythe, â€Å"Testimony of Margaret J. Blythe, MD, FAAP, FSAM, on Behalf of the American Academy of Pediatrics,† Before the Committee on Oversight and Government Reform, United States House of Representatives, April 23, 2008. â€Å"Comprehensive Sex Education Reduces Teen Pregnancy† by Advocates for Youth.Teen Pregnancy and Parenting. Lisa Krueger, Ed. Current Controversies Series. Greenhaven Press, 2011. Advocates for Youth, adapted from â€Å"Comprehensive Sex Education: Research and Results,† September 2009. www. advocatesforyouth. org. â€Å"Sex Education. † Current Issues: Macmillian Social Science Library. Detroit: Gale, 2010. Gale Opposing Viewpoints In Context. Web. 28 Nov. 2011. â€Å"Students Need to Take Responsibility for Their Sexual Health† by Caitlin Myers. Student Life. Karen Miller, Ed. Opposing Viewpoints ® Series. Greenhaven Press , 2011. Caitlin Myers, â€Å"Sex, STIs and Responsibility,† Daily Campus, April 16, 2008.

Developing management skills Essay

By reading the Southfield Case, one can quickly realize that there is definitely lack of direct communication and goal expectations between both Mark Sanders, Vp of account services and Frank Belby, Reginald manager. I believe, there was a lack of supportive communication between Mark and Frank since in the case it was mentioned that Belby viewed professional guidance from Sanders as threatening and it usually caused Belby to distance himself from Frank, which it negatively resulted production. Based on the reading of chapter four of Developing Management Skills, there is a fine line between coaching and counseling and it is extremely challenging for managers to effectively perform both and in the same time make sure that they are not directly ignoring the other persons feelings and confidence. When Frank needed professional advice or when professional criticism was required, instead he mostly got coaching instead of counseling, which resulted in the distance relationship between them, which frank interpreted as a criticism attack on his character. Furthermore, we also learn that in one incident Mark had intervened in a problematic situation between Frank and one of his customers and was able to save that clients contract. By not allowing Frank to resolve the situation, Mark is stretching his duties far too thin and does not allow other employees to delegate effectively, which results in low productivity over all. Based on chapter four readings, the best relationships are based on congruence, which one cannot really find between Mark and Frank’s relationship. Frank is not being clear about his expectations from Mark. It was mentioned in the case that Frank didn’t get the promotion partially because he never directly communicated to frank that he wanted the promotion.

Revolutionary War Essay Example | Topics and Well Written Essays - 250 words

Revolutionary War - Essay Example Washington never understood why slaves would freely choose to fight for their new home. The great majority of slaves only cared about their freedom, so joining the American colonists provided an avenue for this wish. The reason why more blacks joined the Loyalist forces is because they were offering freedom to those who fought. As a result, the Loyalist forces had more men to fight with and had the upper hand in the war. Thousands of blacks chose to side with the British forces because of the promise of freedom—something that the American colonists were not so willing to offer. George Washington barred the recruitment of black soldiers even though they had already fought with whites at Lexington, Concord, and Bunker Hill. This choice proved to be a terrible mistake—although not fatal. It took until the winter of 1777-78 for Washington to reconsider his earlier decision. The American colonists were losing the war and the Continental Army had fallen to only 18,000. Because of these circumstances, Washington finally decided to enlist a regiment of black slaves from Rhode Island. Even though Washington allowed blacks to join the war effort, they were used in basic capacities only. George Washington did not trust blacks at all—he believed that they would take advantage of their new found freedom and run away and desert the army. Washington came from a Southern background and felt that he had to appease South Carolina’s leaders over the issue of slavery. After the war had ended, Washington demanded that former slaves be sent back to their previous masters. This also included the blacks who had fought for the British Loyalists and were now considered American

My Experience of a Stressful Situation Personal Statement

My Experience of a Stressful Situation - Personal Statement Example Since I have adopted a healthy nutrition agenda, my life has become better and it has transcended in the different life realms ever since. I can easily deduce that this has been the biggest task that I have attained to date and there is no reason why I should deny the same. The healthy nutrition was backed up by psychological body systems which aided in my grooming and development. It has been the basis of who I am and how I envision life in its truest fashion. I can easily fathom that these two points have helped me adopt a healthy lifestyle which has facilitated my life like never before. The obstacles that I overcame during this process comprised the habits that I had to get rid of in order to choose a healthy lifestyle. It assisted me immensely towards adequately comprehending how things will shape up and how I as an individual needed to change the course if life in one way or the other. 2. Describe what an "underserved population" means to you. What are ways that a pharmacist ca n serve and impact underserved patient populations? By an underserved population, I hold the opinion that this is one segment of the society which is not being taken care of in a proper manner. These are the people who lack in basic healthcare settings, have a shortage of food and are not in close contact with the availability of water resources. This is the segment that is not being looked after and there are a number of reasons why this has happened within the domains of any society of the world. The underserved population is basically not being given its due share as the entire population must be treated in a fair and equal manner; however, this is hardly the case when one speaks of this form of a segment. As a pharmacist, the role can be of immense significance as far as serving the underserved population is concerned. These are the individuals who can give medicines which are of equal use and effectiveness yet low in price as compared to a higher alternative.

Advanced auditing Essay Example | Topics and Well Written Essays - 2500 words

Advanced auditing - Essay Example Rob Gray tries to identify the scope of social accounting as "the preparation and publication of an account about an organisation's social,environmental,employee,community, customer and other stakeholders' interactions and activities and where possible the consequences of those interactions and activities" With the increase in the business activities backed by globalization, business enterprises have started locating their production facilities across the world, breaking cross border barriers. Such a rapid development, many a times will result in the firms overlooking their social obligations in the interest of maximizing their profits. Hence there has been a good deal of efforts being taken to devise the techniques that measure the contribution of an enterprise to the society. These developments may be considered as the result of the increasing realization of the Social Responsibilities of the enterprises and it becomes necessary that the performance of these enterprises should be s een in the context of their fulfilling their social obligations.According to George Clark "What is now coming to be called Social Auditing is similar in many ways to Financial Auditing except that it is about everything else that an organisation does apart from handling money."There has been a number of proposals put forth to design an extended accounting system that measures the social performance of an enterprise. Linowes has proposed the preparation of a Socio-Economic Operating Statement (SEOS) to show the various social costs and benefits of actions of enterprises. This statement proposes to indicate monetary values of various actions of an enterprise classified in to following categories: Relations with people - to include items like training programmes for handicapped workers, contribution to schools for employees, extra costs incurred in hiring persons from minority or suppressed communities. These items would constitute the contribution of the enterprise in 'improving' the relations with the people. The 'detriments' that need to be shown may be items like postponement of installing safety devices etc Relations with Environment - monetary values of improvements and detriments are to be listed and the net effect shown separately. Relations with Products - In a similar way, monetary values of improvements and detriments are to be listed. Since there is yet to be a significant development to take place in this area, many of the existing models aim at measuring the performance of an enterprise vis--vis the society tales into account the factors like human resource contribution, public contribution, environmental contribution, product or service contribution and net income of the enterprise. 1.2 Environmental Audit: "An environmental audit is a means by which businesses can assess the environmental impacts of their operations. At its core is the measurement and evaluation of all inputs and outputs from the production process." (Australian Government) In the context of the increasing emphasis on protection of environment, environmental accounting and auditing have assumed special importance in recent years. Environmental Accounting aims at measuring the impact of the activities of an organization on the environment. The resultant product is the environmental statement, containing the following among other things to be asserted by the management: A brief description of the activities of the organization and the effect of such activities on the environment as envisaged by the organization A description of the organisation's environmental policy, programme and management systems to implement the stated policies A summary of the figures of emissions which may cause pollution of air and water, waste generation, consumption of raw material, energy, water and other significant environmental aspects. There should also be presented a comparison of such data with the legal norms if any

Historical Figures and their impact on American History Essay

Historical Figures and their impact on American History - Essay Example James Madison: In Focus Being the fourth President of the United States, James Madison has had made his signature over the focal pages of the country’s voluminous biography which unravels into the present day. Moreover, James Madison was said to be the beginning of the exceptional constitutional government of America, which until now, can be felt (Rives 2). As a background, the hero of this story came from Orange County but was born in Port Conway, Virginia on a faithful Wednesday on the 16th of March, 1751. James Madison Sr. was in possession of a substantially organized tobacco plant in their hometown. For a boy who grew up on the state of Virginia, it was only orderly to inherit their father’s labor in the plantations. However, James exhibited great potential even in his youth with a fondness for reading and learning and so they made certain to give their child the proper education (Mattern 13). Then the College of New Jersey, Madison received his schooling from Prin ceton but did so in an impressive and condensed time frame. People of great importance over the nation had already caught a glimpse of the strength that Madison wielded through his contemplation and his statements the same emanation of intellectual competence that his parents saw. He was appointed to form the Virginia Declaration of Rights and took part in the Governor’s Council, Continental Congress as well as the Virginia State Legislature (Vile 7 ). These were the significant moments and occurrences on the life of James Madison that were molding him into the wise engineer of the United States. Probing more of James Madison’s earlier stories would reveal the effects of an upbringing in such a firmly intertwined structure of family and relatives. Even while already on service for the Continental Congress, he could not stay away from his home in Orange County. The place in which he took his first breath into the world would also be the last place he closed his eyes at his age of 85 on June 28, 1836. This special association with his relatives had an effect on his political life as well, as the Madison family was known to have ties with the sheriffs, country lieutenants, justices of the peace and members of the legislature in Virginia (Ketcham 6). Most of his life’s crucial works would be reared from his home state. Living at the period of the American Revolution, he was a pivotal force for its success. His duty was not in the line of battle nor on establishing foreign connections and political negotiations. James Madison was after all a cerebral leader. He went on with his patriotic intentions and concentrated on in the determination of the right kind of government for his country (Mattern 6). After their declaration of independence from Great Britain on the year of 1776, James Madison’s role persisted in creating a better government and in effect, rebuilding a better nation. James Madison had numerous, key contributions for the nat ions. One of the very first is his work of the Virginia report during the year of 1787 which would later be the blueprint for a work with much immensity in a substantial degree of significance--United States Constitution (Kernell 147). Along with Alexander Hamilton and John Jay, James Madison wrote â€Å"The Federalist Papers† from 1787 to 1788 in the hopes of the people of United States to embrace their work. The